abstract：BACKGROUND:Chronic graft-versus-host disease is a common late complication of allogeneic hematopoietic stem cell transplantation. Corticosteroids are the standard initial treatment. Second-line treatment has not been well defined. We evaluated the effectiveness and safety of low doses of alemtuzumab plus low doses of r...

journal_title：Haematologica

authors： Gutiérrez-Aguirre CH,Cantú-Rodríguez OG,Borjas-Almaguer OD,González-Llano O,Jaime-Pérez JC,Solano-Genesta M,Gómez-Guijosa M,Mancias-Guerra C,Tarin L,Gómez-Almaguer D

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Long-term central venous catheters have improved the quality of care for patients with chronic illnesses, but are complicated by obstructions which can result in delay of treatment or catheter removal. DESIGN AND METHODS:This paper reviews thrombolytic treatment for catheter obstruction. Literature from Med...

journal_title：Haematologica

authors： Baskin JL,Reiss U,Wilimas JA,Metzger ML,Ribeiro RC,Pui CH,Howard SC

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Phosphatidylserine exposure by red blood cells is acknowledged as a signal that initiates phagocytic removal of the cells from the circulation. Several disorders and conditions are known to induce phosphatidylserine exposure. Removal of phosphatidylserine-exposing red blood cells generally occurs by macropha...

journal_title：Haematologica

authors： Fens MH,van Wijk R,Andringa G,van Rooijen KL,Dijstelbloem HM,Rasmussen JT,de Vooght KM,Schiffelers RM,Gaillard CA,van Solinge WW

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:MicroRNAs can play an important role in tumorigenesis through post-transcriptional regulation of gene expression, and are not well characterized in follicular lymphoma. DESIGN AND METHODS:MicroRNA profiles of enriched follicular lymphoma tumor cells from 16 patients were generated by assaying 851 human micr...

journal_title：Haematologica

authors： Wang W,Corrigan-Cummins M,Hudson J,Maric I,Simakova O,Neelapu SS,Kwak LW,Janik JE,Gause B,Jaffe ES,Calvo KR

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:The c-Met signaling pathway regulates a variety of biological processes, including proliferation, survival and migration. Deregulated c-Met activation has been implicated in the pathogenesis and prognosis of many human malignancies. We studied the function and prognostic significance of c-Met and hepatocyte ...

journal_title：Haematologica

authors： Xu C,Plattel W,van den Berg A,Rüther N,Huang X,Wang M,de Jong D,Vos H,van Imhoff G,Viardot A,Möller P,Poppema S,Diepstra A,Visser L

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Thrombosis is the major risk factor for death in patients with paroxysmal nocturnal hemoglobinuria. Previous case reports indicate that venous thrombosis in patients with paroxysmal nocturnal hemoglobinuria is amenable to thrombolysis. DESIGN AND METHODS:We reviewed the outcome of thrombolytic therapy for p...

journal_title：Haematologica

authors： Araten DJ,Notaro R,Thaler HT,Kernan N,Boulad F,Castro-Malaspina H,Small T,Scaradavou A,Magnan H,Prockop S,Chaffee S,Gonsky J,Thertulien R,Tarquini R,Luzzatto L

更新日期：2012-03-01 00:00:00

abstract：:Older chronic lymphocytic leukemia patients have poor outcomes with standard treatments and are underrepresented in clinical trials. We retrospectively reviewed outcomes of refractory chronic lymphocytic leukemia patients in two age categories (≥70 and <70 years) treated with single-agent flavopiridol, a drug active i...

journal_title：Haematologica

authors： Stephens DM,Ruppert AS,Blum K,Jones J,Flynn JM,Johnson AJ,Ji J,Phelps MA,Grever MR,Byrd JC

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Preclinical studies have highlighted the activity of lenalidomide in mantle cell lymphoma and its anti-proliferative synergy with dexamethasone. DESIGN AND METHODS:In this prospective, multicenter, phase II study, patients with relapsed/refractory mantle cell lymphoma who were not eligible for, or had relap...

journal_title：Haematologica

authors： Zaja F,De Luca S,Vitolo U,Orsucci L,Levis A,Salvi F,Rusconi C,Ravelli E,Tucci A,Bottelli C,Balzarotti M,Brusamolino E,Bonfichi M,Pileri SA,Sabattini E,Volpetti S,Monagheddu C,Vacca A,Ria R,Fanin R

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Dyskeratosis congenita is a cancer-prone bone marrow failure syndrome caused by aberrations in telomere biology. DESIGN AND METHODS:We studied 65 patients with dyskeratosis congenita and 127 unaffected relatives. Telomere length was measured by automated multicolor flow fluorescence in situ hybridization in...

journal_title：Haematologica

authors： Alter BP,Rosenberg PS,Giri N,Baerlocher GM,Lansdorp PM,Savage SA

更新日期：2012-03-01 00:00:00

abstract：:Genetic events underlying pathogenesis of nodal and extranodal marginal zone lymphoma are not completely understood. We report here a novel t(X;14)(p11.4;q32.33) identified in 4 lymphoma cases: 2 with a mucosa-associated lymphoid tissue lymphoma, one with a nodal marginal zone lymphoma and one with gastric diffuse lar...

journal_title：Haematologica

authors： Baens M,Finalet Ferreiro J,Tousseyn T,Urbankova H,Michaux L,de Leval L,Dierickx D,Wolter P,Sagaert X,Vandenberghe P,De Wolf-Peeters C,Wlodarska I

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:The genetic characterization of chronic lymphocytic leukemia cells correlates with the behavior, progression and response to treatment of the disease. DESIGN AND METHODS:Our aim was to investigate the role of ATM gene alterations, their biological consequences and their value in predicting disease progressi...

journal_title：Haematologica

authors： Guarini A,Marinelli M,Tavolaro S,Bellacchio E,Magliozzi M,Chiaretti S,De Propris MS,Peragine N,Santangelo S,Paoloni F,Nanni M,Del Giudice I,Mauro FR,Torrente I,Foà R

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Polymorphic differences between donor and recipient human leukocyte antigen class I molecules can result in graft-versus-host disease due to distinct peptide presentation. As part of the peptide-loading complex, tapasin plays an important role in selecting peptides from the pool of potential ligands. Class I...

journal_title：Haematologica

authors： Badrinath S,Saunders P,Huyton T,Aufderbeck S,Hiller O,Blasczyk R,Bade-Doeding C

更新日期：2012-01-01 00:00:00

abstract：:Reduction in minimal residual disease, measured by real-time quantitative PCR or flow cytometry, predicts prognosis in childhood B-cell precursor acute lymphoblastic leukemia. We explored whether cells reported as minimal residual disease by flow cytometry represent the malignant clone harboring clone-specific genomic...

journal_title：Haematologica

authors： Øbro NF,Ryder LP,Madsen HO,Andersen MK,Lausen B,Hasle H,Schmiegelow K,Marquart HV

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Most minimal residual disease-directed treatment interventions in current treatment protocols for acute lymphoblastic leukemia are based on bone marrow testing, which is a consequence of previous studies showing the superiority of bone marrow over peripheral blood as an investigational material. Those studie...

journal_title：Haematologica

authors： Volejnikova J,Mejstrikova E,Valova T,Reznickova L,Hodonska L,Mihal V,Sterba J,Jabali Y,Prochazkova D,Blazek B,Hak J,Cerna Z,Hrusak O,Stary J,Trka J,Fronkova E

更新日期：2011-12-01 00:00:00

abstract：:Patients with essential thrombocythemia often complain of various subjective neurological symptoms. This prospective study aims to assess their incidence and response to therapy. Among 37 consecutive patients with essential thrombocythemia, 11 presented with neurological symptoms. Among them 4 had thrombotic events, 7...

journal_title：Haematologica

authors： Billot S,Kouroupi EG,Le Guilloux J,Cassinat B,Jardin C,Laperche T,Fenaux P,Carpentier AF,Kiladjian JJ

更新日期：2011-12-01 00:00:00

abstract：:Overhydrated hereditary stomatocytosis, clinically characterized by hemolytic anemia, is a rare disorder of the erythrocyte membrane permeability to monovalent cations, associated with mutations in the Rh-associated glycoprotein gene. We assessed the red blood cell metabolome of 4 patients with this disorder and showe...

journal_title：Haematologica

authors： Darghouth D,Koehl B,Heilier JF,Madalinski G,Bovee P,Bosman G,Delaunay J,Junot C,Roméo PH

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:In multiple myeloma, expression of cancer testis antigens may provide prognostic markers and potential targets for immunotherapy. Expression at relapse has not yet been evaluated for a large panel of cancer testis antigens which can be classified by varying expression in normal tissue: restricted to testis, ...

journal_title：Haematologica

authors： van Duin M,Broyl A,de Knegt Y,Goldschmidt H,Richardson PG,Hop WC,van der Holt B,Joseph-Pietras D,Mulligan G,Neuwirth R,Sahota SS,Sonneveld P

更新日期：2011-11-01 00:00:00

abstract：:The risk of developing premature ovarian failure and azoospermia is a major concern in long-term survivors treated for Hodgkin's lymphoma. Alkylating chemotherapy containing procarbazine and/or cyclophosphamide causes prolonged azoospermia in 90-100% of men and premature ovarian failure in 5-25% of women under the age...

journal_title：Haematologica

authors： Harel S,Fermé C,Poirot C

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Fms-like tyrosine kinase-3 (FLT3) gene mutations are frequent in acute promyelocytic leukemia but their prognostic value is not well established. DESIGN AND METHODS:We evaluated FLT3-internal tandem duplication and FLT3-D835 mutations in patients treated with all-trans retinoic acid and anthracycline-based ...

journal_title：Haematologica

authors： Barragán E,Montesinos P,Camos M,González M,Calasanz MJ,Román-Gómez J,Gómez-Casares MT,Ayala R,López J,Fuster Ó,Colomer D,Chillón C,Larrayoz MJ,Sánchez-Godoy P,González-Campos J,Manso F,Amador ML,Vellenga E,Lowenberg B

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:There is variability in the outcome of patients with chronic lymphocytic leukemia with apparently the same stage of disease. Identifying genetic variants that influence patients' outcome and response to treatment may provide important insights into the biology of the disease. DESIGN AND METHODS:We investiga...

journal_title：Haematologica

authors： Wade R,Di Bernardo MC,Richards S,Rossi D,Crowther-Swanepoel D,Gaidano G,Oscier DG,Catovsky D,Houlston RS

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:To date, multiple myeloma remains an incurable malignancy due to the persistence of minimal residual disease in the bone marrow. In this setting, monoclonal antibodies against myeloma-specific cell surface antigens represent a promising therapeutic approach, which is however hampered by a lack of appropriate...

journal_title：Haematologica

authors： Atanackovic D,Panse J,Hildebrandt Y,Jadczak A,Kobold S,Cao Y,Templin J,Meyer S,Reinhard H,Bartels K,Lajmi N,Zander AR,Marx AH,Bokemeyer C,Kröger N

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:The myeloproliferative neoplasms, essential thrombocytosis, polycythemia vera and primary myelofibrosis, share the same acquired genetic lesion, but the concept of JAK2 V617F serving as the sole lesion responsible for these neoplasms is under question, and there has been interest in identifying additional mu...

journal_title：Haematologica

authors： Stein BL,Williams DM,O'Keefe C,Rogers O,Ingersoll RG,Spivak JL,Verma A,Maciejewski JP,McDevitt MA,Moliterno AR

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:The World Health Organization separates acute erythroid leukemia (erythropoiesis in ≥50% of nucleated bone marrow cells; ≥20% myeloblasts of non-erythroid cells) from other entities with increased erythropoiesis - acute myeloid leukemia with myelodysplasia-related changes (≥20% myeloblasts of all nucleated c...

journal_title：Haematologica

authors： Bacher U,Haferlach C,Alpermann T,Kern W,Schnittger S,Haferlach T

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Allogeneic hematopoietic cell transplantation is a potentially curative treatment for patients with acute lymphoblastic leukemia. However, the majority of older adults with acute lymphoblastic leukemia are not candidates for myeloablative conditioning regimens. A non-myeloablative preparative regimen is a re...

journal_title：Haematologica

authors： Ram R,Storb R,Sandmaier BM,Maloney DG,Woolfrey A,Flowers ME,Maris MB,Laport GG,Chauncey TR,Lange T,Langston AA,Storer B,Georges GE

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:In trials designed to evaluate new therapies for hematologic malignancies, end points such as leukemia-free survival are often used as surrogates for overall survival in acute leukemia. We aimed to assess whether leukemia-free survival is an acceptable statistical surrogate for overall survival when applied ...

journal_title：Haematologica

authors： Buyse M,Michiels S,Squifflet P,Lucchesi KJ,Hellstrand K,Brune ML,Castaigne S,Rowe JM

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:LMO2 is highly expressed at the most immature stages of lymphopoiesis. In T-lymphocytes, aberrant LMO2 expression beyond those stages leads to T-cell acute lymphoblastic leukemia, while in B cells LMO2 is also expressed in germinal center lymphocytes and diffuse large B-cell lymphomas, where it predicts bett...

journal_title：Haematologica

authors： Malumbres R,Fresquet V,Roman-Gomez J,Bobadilla M,Robles EF,Altobelli GG,Calasanz MJ,Smeland EB,Aznar MA,Agirre X,Martin-Palanco V,Prosper F,Lossos IS,Martinez-Climent JA

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Epigenetic changes are involved in the extinction of the B-cell gene expression program of classical Hodgkin's lymphoma. However, little is known regarding epigenetic similarities between cells of classical Hodgkin's lymphoma and plasma cell myeloma, both of which share extinction of the gene expression prog...

journal_title：Haematologica

authors： Seitz V,Thomas PE,Zimmermann K,Paul U,Ehlers A,Joosten M,Dimitrova L,Lenze D,Sommerfeld A,Oker E,Leser U,Stein H,Hummel M

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:In a study of childhood acute lymphoblastic leukemia (CoALL 06-97 study), the in vitro sensitivity of the patients' cells to prednisolone, vincristine and asparaginase was introduced as a new additional risk parameter for treatment stratification. In parallel in vivo treatment response was assessed by determ...

journal_title：Haematologica

authors： Escherich G,Tröger A,Göbel U,Graubner U,Pekrun A,Jorch N,Kaspers G,Zimmermann M,zur Stadt U,Kazemier K,Pieters R,Den Boer ML,Horstmann M,Janka GE,CoALL study group, Hamburg, Germany.

更新日期：2011-06-01 00:00:00

abstract：:Alemtuzumab serum levels and clinical response after subcutaneous administration (10 mg 3 times/week for six weeks) have been explored in 29 chronic lymphocytic leukemia patients receiving the monoclonal antibody as consolidation. Serum concentrations after each administration gradually increased during the first week...

journal_title：Haematologica

authors： Montagna M,Montillo M,Avanzini MA,Tinelli C,Tedeschi A,Visai L,Ricci F,Vismara E,Morra E,Regazzi M

更新日期：2011-06-01 00:00:00

abstract：:Chronic lymphocytic leukemia is frequently associated with immune disturbances. The relationship between chronic lymphocytic leukemia and autoimmune cytopenias, particularly autoimmune hemolytic anemia and immune thrombocytopenia, is well established. The responsible mechanisms, particularly the role of leukemic cells...

journal_title：Haematologica

authors： Hodgson K,Ferrer G,Montserrat E,Moreno C

更新日期：2011-05-01 00:00:00

abstract：:The mouse pro-B cell line Ba/F3 has gained major interest as a model system to investigate oncogenic tyrosine kinases and to determine the efficacy of kinase inhibitors. While Ba/F3 cells are suitable to study oncogenic kinases derived from various cell types, the signaling networks in Ba/F3 cells are B-cell specific....

journal_title：Haematologica

authors： Kleppe M,Mentens N,Tousseyn T,Wlodarska I,Cools J

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Myeloproliferative neoplasms constitute a group of diverse chronic myeloid malignancies that share pathogenic features such as acquired mutations in the JAK2, TET2, CBL and MPL genes. There are recent reports that a JAK2 gene haplotype (GGCC or 46/1) confers susceptibility to JAK2 mutation-positive myeloprol...

journal_title：Haematologica

authors： Olcaydu D,Rumi E,Harutyunyan A,Passamonti F,Pietra D,Pascutto C,Berg T,Jäger R,Hammond E,Cazzola M,Kralovics R

更新日期：2011-03-01 00:00:00

abstract：:ALK-positive large B-cell lymphoma is a rare subtype of lymphoma, and most cases follow an aggressive clinical course with a poor prognosis. We examined an ALK-positive large B-cell lymphoma case showing an anti-ALK immunohistochemistry pattern distinct from those of 2 known ALK fusions, CLTC-ALK and NPM-ALK, for the ...

journal_title：Haematologica

authors： Takeuchi K,Soda M,Togashi Y,Ota Y,Sekiguchi Y,Hatano S,Asaka R,Noguchi M,Mano H

更新日期：2011-03-01 00:00:00

abstract：:In patients with low and intermediate risk myelodysplastic syndrome and deletion 5q (del(5q)) treated with lenalidomide, monitoring of cytogenetic response is mandatory, since patients without cytogenetic response have a significantly increased risk of progression. Therefore, we have reviewed cytogenetic data of 302 p...

journal_title：Haematologica

authors： Göhring G,Giagounidis A,Büsche G,Hofmann W,Kreipe HH,Fenaux P,Hellström-Lindberg E,Schlegelberger B

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Pediatric acute myeloid leukemia is a heterogeneous disease characterized by non-random genetic aberrations related to outcome. The genetic subtype is currently detected by different diagnostic procedures which differ in success rate and/or specificity. DESIGN AND METHODS:We examined the potential of gene e...

journal_title：Haematologica

authors： Balgobind BV,Van den Heuvel-Eibrink MM,De Menezes RX,Reinhardt D,Hollink IH,Arentsen-Peters ST,van Wering ER,Kaspers GJ,Cloos J,de Bont ES,Cayuela JM,Baruchel A,Meyer C,Marschalek R,Trka J,Stary J,Beverloo HB,Pieters R

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Classical Hodgkin's lymphoma is characterized by a minority of neoplastic cells surrounded by a heterogeneous background population of non-neoplastic cells including lymphoma-associated macrophages. High levels of expression of both the monocyte/macrophage lineage-associated antigens CD68 and CD163 have been...

journal_title：Haematologica

authors： Kamper P,Bendix K,Hamilton-Dutoit S,Honoré B,Nyengaard JR,d'Amore F

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Oral deferiprone was suggested to be more effective than subcutaneous desferrioxamine for removing heart iron. Oral once-daily chelator deferasirox has recently been made commercially available but its long-term efficacy on cardiac iron and function has not yet been established. Our study aimed to compare th...

journal_title：Haematologica

authors： Pepe A,Meloni A,Capra M,Cianciulli P,Prossomariti L,Malaventura C,Putti MC,Lippi A,Romeo MA,Bisconte MG,Filosa A,Caruso V,Quarta A,Pitrolo L,Missere M,Midiri M,Rossi G,Positano V,Lombardi M,Maggio A

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Persistent mixed chimerism represents a state in which recipient and donor cells stably co-exist after hematopoietic stem cell transplantation. However, since in most of the studies reported in literature the engraftment state was observed in the nucleated cells, in this study we determined the donor origin ...

journal_title：Haematologica

authors： Andreani M,Testi M,Gaziev J,Condello R,Bontadini A,Tazzari PL,Ricci F,De Felice L,Agostini F,Fraboni D,Ferrari G,Battarra M,Troiano M,Sodani P,Lucarelli G

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:During the final stages of differentiation of mammalian erythroid cells, the chromatin is condensed and enucleated. We previously reported that Rac GTPases and their downstream target, mammalian homolog of Drosophila diaphanous 2 (mDia2), are required for enucleation of in vitro cultured mouse fetal liver er...

journal_title：Haematologica

authors： Ji P,Yeh V,Ramirez T,Murata-Hori M,Lodish HF

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Transplantation from an HLA-matched sibling is the treatment of choice for young patients with acquired severe aplastic anemia. For older patients, the acceptable upper age limit for transplantation as first-line treatment varies. The current analysis, therefore, sought to identify age or ages at transplanta...

journal_title：Haematologica

authors： Gupta V,Eapen M,Brazauskas R,Carreras J,Aljurf M,Gale RP,Hale GA,Ilhan O,Passweg JR,Ringdén O,Sabloff M,Schrezenmeier H,Socié G,Marsh JC

更新日期：2010-12-01 00:00:00